Prognostic Impact of Cytogenetic Abnormalities in Multiple Myeloma
نویسندگان
چکیده
منابع مشابه
Prognostic Impact of Cytogenetic Abnormalities in Multiple Myeloma
The identification of specific cytogenetic abnormalities by interphase fluorescence in situ hybridization (i-FISH) has become a routine procedure for prognostic stratification of multiple myeloma (MM) patients. In this study, the prognostic significance of cytogenetic abnormalities detected by interphase fluorescence in situ hybridization (iFISH) in 229 newly diagnosed multiple myeloma patients...
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Fluorescence in situ hybridization evaluation is essential for initial risk stratification in multiple myeloma. While the presence of specific cytogenetic high-risk abnormalities (HRA) is known to confer a poor prognosis, less is known about the cumulative effect of multiple HRA. We studied 1181 patients with newly diagnosed multiple myeloma who received novel agents as first-line therapy. High...
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Multiple Myeloma is a malignant plasma cell disorder characterized by the development of end organ damages resulting in hypercalcemia, renal insufficiency, anemia and osteolytic lesions. The therapeutic options for multiple myeloma have markedly increased over the last decade. In particular, the development of proteasome inhibitors like bortezomib and carfilzomib and the immunomodulatory agents...
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Introduction: Multiple myeloma is a heterogeneous disease with different survival times among patients. Accurate prediction of prognosis in multiple myeloma is essential, as patients with a shorter survival time may require early bone marrow transplantation (BMT) and more advanced chemotherapy as a part of their first-line treatment. In the present study, a parameter, depicted by ga...
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ژورنال
عنوان ژورنال: Medicine
سال: 2016
ISSN: 0025-7974
DOI: 10.1097/md.0000000000003521